
Dr. Chris Centeno and Dr. John Schultz embark on an idea to apply stem cells to treat orthopedic injuries in a small two-man clinic in Colorado.
Regenexx begins its Patient Registry – a database for tracking patient outcomes.

Regenexx C (cultured) begins in Colorado.
Regenexx releases the first of its free publications – A collection that will ultimately include both Free Reports and Free eBooks.
Dr. Chris Centeno and Dr. John Schultz complete a two-year, IRB-approved research study of the use of both culture-expanded and same-day stem cells to treat knee and hip arthritis and low-back degenerative disc disease.
First blog post on Regenexx.com (started 2007) is published.
Regenexx PL (platelet lysate), a highly specialized derivative of platelet-rich plasma, begins.

Regenexx unveils their world-class laboratory at its Broomfield, Colorado headquarters, lead by a doctorate-level research team.

Regenexx SCP, a super-concentrated version of platelet rich plasma, begins.

Regenexx-SD, a same-day, orthopedic stem cell treatment, begins.

Dr. Rob Kramberg of the Rehabilitation Medical Center of New Jersey, is brought in as the first affiliate to the Regenexx Network.

Regenexx C begins in Grand Cayman
- Health Link Medical Center – Oceanside, CA
- Rejuv Medical – Waite Park, MN
- Regenexx Cayman
- ProMedica
- Health Link Medical Center – San Rafael, CA
- Regenexx Pittsburgh
- New ReGeneration Orthopedics
- Regenexx Australia
- StemCell ARTS – Virginia
- Chicago Arthritis and Regenerative Medicine

Fellowship program introduced for mentorship and training of up-and-coming physicians.

Regenexx PLM & Regenexx AD Begin
- UCLA Health/Southern California Orthopedic Institute – Van Nuys, CA
- TotalCare Health & Wellness
- Beacon Orthopaedics & Sports Medicine
- Regenexx Des Moines
- Wasatch Pain Solutions
- Vermont Regenerative Medicine
- Health Link Medical Center – Beverly Hills, CA
- UCLA Health/Southern California Orthopedic Institute – Thousand Oaks, CA
- Columbia Pain Management
- Bodyworks Musculoskeletal Medicine
- RegenOrthoSport – Dallas, TX

First self-funded employer, Meredith, adds Regenexx to their health benefits plan, providing a cost saving solution that gives employees an alternative to orthopedic surgery.
- Manzano Medical Group
- Regenexx Las Vegas
- Mountain View Rehabilitation
- Regenexx Philadelphia
- RegenOrthoSport – Hyderbad, India
- Algone Interventional Pain Clinic
- Texas Interventional Orthopedic and Regenerative Medicine
- Center for Orthopedic Regenerative Medicine

Regenexx publishes the world’s largest stem cell safety paper in any medical indication.
Regenexx A2M Begins
- Ortho Regenerative
- Nashville Regenerative Orthopedics
- RestorePDX
- Rejuv Medical – Savage, MN
- Chun Chuan Clinic
- RegenOrthoSport – Mumbai, India
- Eastern Idaho Spine, Sports and Rehab Center

First randomized control trial for knee arthritis completed in its third year.
- AlgoCells
- Northwest Center for Regenerative Medicine
- AMR Pain and Spine Clinic
- Interventional Orthopedics of Atlanta
- Centeno-Schultz Clinic – Lone Tree, CO
- Cutting Edge Integrative Pain Centers
- Restore Orthopedics & Sports Medicine
- Functional Rehabilitation Experts
- Advanced PainCare and BioHealth Institute
- Interventional Orthopedics CT
- Momenta Pain Care
- River City Rehabilitation & Spine Specialists
- Center for Interventional Pain and Spine
- Premier Medical Group
- Elite Pain & Health
- Interventional Pain Care
- Coastal Regenerative Orthopedics and Wellness Center
Twenty-sixth research publication.
The Regenexx Affiliate Network hits 62 sites.

Regenexx receives the Employer Health Innovation Roundtable (EHIR) Traction Award at Cohort 3 (October) for a record number of matches.
- Premier Orthopaedics
- Physio Logic Medicine
- Spine and Pain Centers
- Ospina Medical Group

Regenexx’s second randomized controlled trial is published on shoulder rotator cuff tears.