Regenexx Impact Study

See what wear-and-tear MSK could be costing your plan — from plan spend, employee count, or covered lives. No claims data needed.

5 min No data needed

Inputs

Plan profile

Funnel assumptions

Pre-filled from current reference assumptions. Override for what-if scenarios; changes are local to this calculator.

Estimated savings opportunity

$0

Base case


Range (15–20% MSK · ±4pp savings)

$0

Low

$0

Base

$0

High

Step by step

How the estimate is built

Each step narrows total plan spend down to what Regenexx can address.

Step Math % of total medical Amount

Catalog · Top procedures avoided

Net savings per patient over time

Joints: Ankle · Elbow · Hip · Knee · Shoulder · Spine · Thumb · Wrist

Joint Surgery avoided Modality Surgical $ 12-mo 24-mo (base) 48-mo
Lumbar Spine Lumbar Fusion (1-3 levels) SD $103K $92,428 $92,428 $89,198
Knee Knee TKA SD (IO)-Hernigou $54K $37,266 $37,266 $37,266
Shoulder Total Shoulder Arthroplasty (TSA) SD (IO) $62K $45,498 $45,498 $45,498
Hip Hip THA SD (IO) - Hernigou KL3 $50K $33,491 $32,788 $31,382

See the full list in the report  â†’

Bias correction: surgery conversion rates calibrated +1.5pp per the QoIP failure-rate methodology. Modality codes — SCP: Same-day Cellular Procedure · SD: Same-day Disc · IA: intra-articular · IO: intra-osseous (Hernigou) · PL: perineural lavage.

Real-world evidence · Duke 2026 · medRxiv

Independent, peer-reviewed, and durable through 4 years.

$45K average payer savings per spine case vs. spinal fusion (Duke, 48 mo)  Â·  $13.5K per knee case vs. total knee replacement

36%

Fewer outpatient visits

4.6 vs. 7.2 mean · p<0.001

37%

Fewer PT visits

10.1 vs. 15.9 mean · p<0.001

84%

Fewer knee X-rays

15% vs. 94% of patients · p<0.001

20.5%

Lower opioid Rx rate

35% vs. 44% of patients · p=0.02

13x

Fewer subsequent fusions

<1% vs. 13.5% at 48 mo

4x

Longer durability vs. TKA

8.5% at 48 mo vs. 11.3% subsequent knee procedures within 12 mo of TKA

Two retrospective cohort studies by Duke researchers (DCRI · Duke-Margolis) of commercial claims data — orthobiologics vs. spinal fusion, lumbar decompression, total knee replacement, and arthroscopic meniscectomy. Regenexx provided clinical data only — not study design, execution, or analysis.

Choose your next step

Two more analyses, sized to your population.

Both are free and produce a branded web report you can save as a PDF to share with your benefits committee.

Start here

Claims Analysis

  • Which of your procedures are Regenexx-eligible, CPT by CPT
  • What each one costs through Regenexx versus the surgical alternative
  • An interactive report you can save as a PDF for your benefits committee
Request a Claims Analysis →

Also available

Geo Access

  • How far your people actually are from care, location by location
  • Today's network and the pending expansion, side by side
  • An interactive coverage map showing where the gaps are
Run a Geo Access report →

Where the assumptions come from

Sources

Source What it supports

Kaiser Permanente

Employer MSK treatment costs ~15% of total medical costs.

Evernorth — Americans in Motion

Wear-and-tear = 63.5% of MSK spend; top five body regions account for 80% of wear-and-tear spend; back / knee / neck / hip / shoulder breakdown.

Regenexx Company-wide Scorecard

Aggregate savings rate from the 2025 Company-wide Scorecard: 512 accounts · $98,234,168 fair-market value · $35,184,605 Regenexx cost · $63,049,563 savings = 64.2%.

See the full list in the report  â†’

Industry context

The MSK spend opportunity — sources and framing

Employer-facing summary of the funnel from total medical spend → MSK → wear-and-tear → elective orthopedic opportunity. Use this as the narrative when sharing the estimator output with a plan sponsor.

MSK as a share of total medical spend

For self-funded employers, musculoskeletal care is consistently one of the largest medical cost categories. The most defensible general benchmark is that MSK represents roughly 15–20% of total medical spend for most large employer groups. Kaiser Permanente cites MSK treatment costs as nearly 15% of total employer medical costs. A Health Action Council / UnitedHealth Group analysis showed MSK at 13% of spend in that employer-coalition population, while UnitedHealthcare separately reports MSK costing employers $40.51 PMPM in its 2024 book of business. A National Business Group on Health estimate places MSK at approximately 31% of total employer medical expenses, but that should be treated as a high-end benchmark rather than the safest average.

Two-thirds of MSK spend is wear-and-tear

The biggest opportunity is not "all MSK" equally — it's the wear-and-tear / degenerative MSK funnel. Evernorth's commercial-claims analysis defines wear-and-tear MSK as strains, sprains, tendon/ligament tears, ruptured spinal discs, and degenerative joint changes. In commercially insured members under 65, Evernorth found that wear-and-tear conditions account for 63.5% of all MSK-related utilization and cost, compared with 18.6% for trauma, 16.9% for autoimmune/rheumatologic disease, and 1.0% for other MSK conditions. Using the 15–20% total-medical-spend benchmark, wear-and-tear MSK alone represents roughly 9.5–12.7% of total medical spend for a self-funded employer.

Five anatomic regions concentrate the spend

Within wear-and-tear MSK, the spend is highly concentrated. Evernorth found that just five anatomic areas — back, lower leg/knee, neck, hip, and shoulder — account for 80% of wear-and-tear MSK utilization and cost. That equals approximately 50.8% of total MSK spend, or about 7.6–10.2% of total medical spend at the 15–20% MSK benchmark.

  • Back — 29% of wear-and-tear spend
  • Lower leg / knee — 16%
  • Neck — 13%
  • Hip — 11%
  • Shoulder — 11%

Elective orthopedic procedures — a controllable subset

Elective orthopedic surgeries and procedures are a smaller subset of the wear-and-tear bucket, but they are a major controllable cost category. Public sources don't provide one universal benchmark for "elective ortho as a percent of MSK spend" because definitions vary across inpatient surgery, outpatient surgery, injections, imaging, facility fees, implants, and related professional claims. The safer statement: elective orthopedic procedures are not the majority of MSK spend by themselves, but they're a high-cost, highly actionable subset within wear-and-tear — spine surgery, joint procedures, MRIs, injections, and arthroscopies all sit within this funnel.

The low-value-care opportunity

The low-value-care opportunity is substantial. EviCore/Evernorth cites an estimate that 25–40% of MSK care spending is wasteful or ineffective, with degenerative meniscus arthroscopy highlighted as one example of low-value MSK care when evidence-based conservative care would often be more appropriate. Spine surgery is one of the clearest examples of overuse risk. Lown Institute's Medicare analysis found that U.S. hospitals performed more than 200,000 unnecessary back surgeries over three years, costing Medicare about $2B on average, and that 14% of spinal fusions/laminectomies met overuse criteria. Medicare data, not commercial employer data, but it supports the broader point that back surgery has a meaningful low-value-care component.

Recommended market message

MSK typically represents about 15–20% of total medical spend for self-funded employers. Roughly two-thirds of that MSK spend is driven by wear-and-tear or degenerative conditions, meaning approximately 10–13% of total medical spend is tied to this category alone. Within wear-and-tear MSK, back, knee, hip, neck, and shoulder conditions account for the majority of the spend. Elective orthopedic surgeries, injections, imaging, and related procedures are a major controllable subset of the wear-and-tear funnel — with spine surgery, joint procedures, MRIs, injections, and arthroscopies representing some of the highest-cost and most avoidable areas.

Caveat: The estimator multiplies through three industry-typical ratios. It's directionally correct as a first-pass sizing tool — actual MSK share, wear-and-tear mix, and per-CPT eligibility vary by plan.